Programme Schedule

Sunday, September 17, 2017
14:00 – 17:00 Registration
14:00 – 17:00 Setting-up posters, (also those selected for short oral presentation)
Keynote Lectures
Chair: Doriano Fabbro
17:00 – 17:15 Doriano Fabbro, PIQUR, Basel, Switzerland
Opening Remarks: 9th IPK and 30 years of kinase drug discovery
17:15 – 18:00 Nathanael Gray, Dana-Farber Cancer Institute, Harvard, USA
Targeting cancer using covalent inhibitors and small molecule degraders
18:00 – 18:45 Kevan Shokat, UC San Francisco, San Francisco, USA
Beyond orthosteric kinase inhibitors
18:45 Get-together reception
Monday, September 18, 2017
Understanding fundamental function of protein kinases
Chair: Lorenzo Pinna
08:30 – 09:00 Friedrich Herberg, University of Kassel, Kassel, Germany
Functional implications of disease-related protein kinase mutations
09:00 – 09:30 Susan Taylor, Taylor Laboratory, UC San Diego, San Diego, USA
Dynamic assembly of macromolecular complexes: from PKA to LRRK2
09:30 – 10:00 Lorenzo Pinna, University of Padova, Padova, Italy
Cell viability without CK2: conceptual insights and practical hints
10:00 – 10:15 Pawlowski Krzysztof, Warsaw University, Warsaw, Poland
Novel kinase families – why easy to miss, why hard to find
10:15 – 10:45 Natarajan Kannan, University of Georgia, Athens, USA
Investigating protein kinase mechanisms in the big data era
10:45 – 11:15 Vincent Tagliabracci, SMC, Dallas, USA
Novel atypical protein kinases
11:15 – 11:30 Coffe break
11:30 -12:00 Dario Alessi, University of Dundee, Dundee, UK
Regulation and function of the Parkinson’s LRRK2 protein kinase
12:00 -12:30 Alexandra Newton, UC San Diego, San Diego, USA
Balancing Protein Kinase C Activity: Loss-of-function vs Gain-of-Function mutations in disease
12:30 -13:00 Asko Uri, University of Tartu, Tartu, Estonia
Construction of biligand inhibitors of protein kinases for biomedical research
13:00 – 14:00 Lunch
Kinase Inhibitors as tools for understanding target biology
Chair: Susan Taylor
14:00 – 14:30 Stefan Knapp, Frankfurt University, Frankfurt, Germany
Selective targeting of kinase catalytic and non-catalytic function
14:30 – 15:00 Natalia Jura, UC San Francisco, San Francisco,USA
Molecular mechanisms for atypical functions of pseudokinases
15:00 – 15:30 Roger Daly, Monash University, Melbourne, Australia
Kinase and pseudokinase signalling networks in human cancer
15:30 – 16:00 Stefano Ferrari, University of Zurich, Zurich, Switzerland
Targeting kinases through inhibition of the dual specificity phosphatase CDC25
16:00 – 16:15 Coffee break
16:15- 16:45 John Elkins, SGC, Oxford, UK
Activation mechanism of Aurora B kinase
16:45-17:00 Piotr Setny, University of Warsaw, Warsaw, Poland
Water-mediated cooperativity of substrate binding in PKA
17:00-17:30 Andrew Shaw, Genentech, San Francisco, US
Mechanisms of allosteric RAF kinase activation
17:30-18:00 Eileen Kennedy, UC San Diego, San Diego, USA
Targeting AKAP signaling complexes with constrained peptide scaffolds
Tuesday, September 19, 2017
Structural and computational approaches for kinases and drug discovery
Chair: Michal Vieth
08:30 – 09:00 Gennady Verkhivker, Chapman University, Orange, USA
Multiscale modeling and network-based systems biology analysis of protein kinase regulation by the Hsp90-Cdc37 chaperone system
09:00 – 09:30 Benoit Roux, University of Chicago, Chicago, USA
Targeting metastable states of Abl and other kinases
09:30 – 10:00 Richard Engh, University of Tromso, Tromso, Norway
Protein kinase flexibility and inhibitor binding energies
10:00 – 10:15 Mayrhofer Johanna, University of Innsbruck, Innsbruck, Austria
Function and architecture of the macromolecular Gpr161:PKA complex
10:15 -10:30 Lalima Ahuja, UC San Diego, San Diego, USA
Understanding the dynamics of ‘Pseudokinase’ mutations
10:30 -10:45 Paweł Daniluk, University of Warsaw, Warsaw, Poland
Multiple alignment of protein kinases using fully automated methods
10:45 – 11:15 Andrzej Kolinski, University of Warsaw, Warsaw, Poland
Unrestrained, fully flexible, protein-peptide docking
11:15 – 11:30 Coffe break
11:30 – 12:00 Alexandr Kornev, UCSD, San Diego, USA
Self organization, entropy and allostery in protein kinases
12:00-12:30 Chris Murray, Astex Pharmaceuticals, Cambridge, UK
Computational and Fragment-based methods for the identification of kinase inhibitors
12:30-13:00 short talks
13:00 – 14:00 Lunch
Kinase Drug Discovery: Reversible to covalent inhibitors
Chair: Stefan Laufer
14:00 – 14:30 Stefan Laufer, Tuebingen University, Tuebingen, Germany
EGFR triple mutant: Recent set-backs and new hopes in fighting mutant non-small cell lung cancer
14:30 – 15:00 Michael Eck, Dana-Farber Cancer Institute, Harvard, USA
Overcoming drug-resistant EGFR mutants with allosteric inhibitors
15:00 – 15:30 Philip Low, Purdue University, West Lafayette, USA
A new general mechanism of kinase regulation of membrane transporters: Novel opportunities for therapeutic interventions
15:30 –15:45 Gopal Sapkota, University of Dundee, Dundee, UK
The FAM83 family of proteins: Anchors for Casein Kinase 1 isoforms?
15:45-16:15 Mart Loog, University of Tartu, Tartu, Estonia
Disordered CDK inhibitors as multi-input signal processors controlling the key decision points in the cell cycle
16:15 – 16:30 Coffee break
16:30 – 17:00 Gianluigi Veglia, University of Minnesota, Minneapolis, US
Conformational dynamics dictate normal and aberrant function of PKA
17:00 – 17:30 Krzysztof Brzozka, Selvita S.A., Cracov, Poland
Discovery and clinical development of a novel, dual PIM-FLT3 inhibitor for the treatment of hematological malignancies
17:30 – 18:00 Attila Remenyi, Hungarian Academy of Sciences, Budapest, Hungary
The molecular logic of MAP kinase mediated signaling: from structures to systems
18:00 – 20:00 Poster session and refreshments
Wednesday, September 20, 2017
Kinases of pathogens and their hosts during the infection process
Chair: Christian Doerig
08:30 – 09:00 Christian Doerig, Monash University, Melbourne, Australia
Kinomics of infectious disease systems: a source of novel targets for anti-infectives
09:00 – 09:30 Raymond Hui, SGC Toronto (TBC), Toronto, Canada
Structural biology and inhibition of parasite-encoded kinases
09:30 – 10:00 Paul Atwood, University of Western Australia, Perth, Australia
Bacterial histidine kinases as potential therapeutic targets
10:00 – 10:30 Thomas Baumert, Inserm – University of Strasbourg, Strasburg, France
Chemoprevention of hepatocellular carcinoma targeting EGFR
10:30-11:00 Yasushi Kawaguchi, University of Tokyo, Tokyo, Japan
Virus-encoded kinases
11:00 – 11:30 Coffee break
11:30-12:00 Gordon Langsley, Inserm, Institut Cochin, Paris, France
cAMP-dependent PKA-mediated processes in apicomplexan parasite-infected host cells
12:00-12:30 Andrew Tobin, University of Glasgow, Glasgow, Scotland
Antimalarial drug discovery targeting Plasmodium NEKs and CLKs
12:30 – 13:00 Kojo Mensa-Wilmot, University of Georgia, Athens, USA
Trypanosome protein kinase inhibitors for biology and drug discovery
13:00-14:00 Lunch
Challenges in molecular biology and biophysics part I
Chair: Richard Bayliss
14:00 -14:30 Richard Bayliss, University of Leicester, Leicester, UK
Structural and functional consequences of protein phosphorylation
14:30 -15:00 Kim Choel, Baylor College of Medicine, Houston, US
Structural Basis for cGMP dependent protein kinase Iα Inhibition by a balanol like compound, N46
15:00 – 15:30 Zygmunt Derewenda, University of Virginia, Charlottesville, USA
RSK family of Ser/Thr kinases: new developments in structural and physiological characterization
15:30 –16:00 Brent Osborne, Defined Health, Florham Park NJ, USA
Novel activators of type I cGMP-dependent protein kinase
16:00 – 16:15 Coffee break
16:15 – 16:45 Ivan Plaza-Menacho,  Spanish National Cancer Research Center, Madrid, Spain
RET functions as a dual-specificity kinase that requires allosteric inputs from juxtamembrane elements
16:45 – 17:00 Thomas Hanke, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
Identification and development of a type I, type II and type III LIM kinase inhibitor and discovery of a chemical probe for LIMK1/LIMK2
Thursday September 21, 2017
Challenges in molecular biology and biophysics part II
Chair: Jarosław Poznański
09:00 – 09:30 Jaroslaw Poznanski, Institute of Biochemistry and Biophysics PAS, Warsaw, Poland
Protein kinase: a biomolecular cage for thermodynamics studies of a halogen bond
09:30 – 10:00 Wojciech Bal, Institute of Biochemistry and Biophysics PAS, Warsaw, Poland
Xaa-His peptides – candidate cupric chaperones and metallohormones
10:00 – 10:30 Maria Bretner, Warsaw University of Technology, Faculty of Chemistry, Warsaw, Poland
Synthesis of new aminoalkyl derivatives of TBBi and TBBt, as dual inhibitors of CK2 and PIM1 kinases and their biological properties
10:30 – 11:00 Dariusz Pianka, BioRad – Sponsors lecture
Normalization in Western Blotting
11:00 – 11:15 Coffe break
11:15 – 11:45 Michał Dadlez, Institute of Biochemistry and Biophysics PAS, Warsaw, Poland
Protein structural dynamics – surprises from HDex
11:45 – 12:15 Tomasz Sarnowski, Institute of Biochemistry and Biophysics PAS, Warsaw, Poland
The SWI/SNF ATP-dependent chromatin remodeling complexes are involved in the control of metabolic processes in plants and human
12:15 – 12:30 Closing remarks and end of meeting
12:30 – 14:00 Lunch





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